$1,354.00 ▼ 0.79% ▲ 46.48% $1.21T Obesity & diabetes The obesity and diabetes leader (Mounjaro, Zepbound, Foundayo pill), now the world's most valuable drugmaker. $40.31 ▲ 0.02% ▼ 11.76% $177.81B Obesity & diabetes The inventor of Ozempic and Wegovy, now fighting falling prices, generics and Eli Lilly. $547.09 ▲ 0.85% ▲ 33.61% $138.58B Rare diseases Near-monopoly in cystic fibrosis, plus the first CRISPR therapy and a new non-opioid painkiller. $50.33 ▼ 0.16% ▲ 7.93% $102.17B Vaccines & mRNA Large British drugmaker in vaccines, HIV and cancer, which bought Nuvalent for its lung cancer pills. $254.19 ▲ 5.27% ▲ 935.82% $101.47B Vaccines & mRNA The mRNA vaccine pioneer, now betting on a personalized cancer vaccine with Merck. $192.28 ▲ 8.24% ▲ 215.16% $41.21B Cancer Maker of Rasonque, the first drug aimed broadly at RAS, the gene behind most pancreatic cancers. $69.57 ▲ 1.25% ▲ 70.47% $16.98B Cancer Profitable cancer company built on Cabometyx, now trying to line up its successor, zanzalintinib. $72.77 ▲ 1.59% ▼ 1.29% $7.87B Cancer Profitable cortisol specialist whose new ovarian cancer drug took off after an FDA rejection in Cushing's syndrome. $277.62 ▲ 5.72% ▲ 65.03% $7.75B Brain & pain Brain disease company with two FDA decisions due within five weeks, for epilepsy and essential tremor. $50.07 ▲ 3.11% ▼ 9.16% $4.83B Gene editing Co-owner of Casgevy, the first CRISPR medicine, now testing one-time gene edits for heart disease. $28.49 ▼ 0.21% ▲ 3.83% $3.23B Immunology New rival to Amgen's Tepezza in thyroid eye disease, with its first drug approved in June 2026. $29.41 ▲ 4.03% ▼ 27.69% $1.76B Rare diseases Maker of mitapivat, a pill for rare blood disorders, waiting for an FDA decision in sickle cell disease. $4.83 ▲ 10.27% ▲ 22.28% $992.56M Rare diseases Single-drug company with an inhaled medicine for a rare lung disease that has no approved treatment. $9.00 ▲ 4.65% ▲ 51.77% $522.9M Rare diseases Small company whose cell therapy for Duchenne muscular dystrophy faces an FDA decision on 22 November 2026. $3.55 ▲ 2.01% ▼ 23.16% $99.05M Heart & kidney Tiny kidney drug company whose phosphate pill has been rejected twice over an outside factory. No companies in this area yet.